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RGDP-009A

RGD-targeted Proapoptotic Peptide

H-Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-Gly-DLys-DLeu-DAla-DLys-DLeu-DAla-DLys-DLys-DLeu-DAla-DLys-DLeu-DAla-DLys-NH2 (trifluoroacetate salt)
(Disulfide Bridge Cys1-Cys4 and Cys2-Cys3)

$327.00
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Product Description

This sequence is a targeted proapoptotic peptide. The C-terminal RGD-4C peptide (ACDCRGDCFC) binds preferentially to integrins at sites of tumor angiogenesis. Two glycines provide spacer, and D(KLAKLAK)2 is the proapoptotic peptide composed of D-amino acids.

SEQUENCE: H-Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-Gly-DLys-DLeu-DAla-DLys-DLeu-DAla-DLys-DLys-DLeu-DAla-DLys-DLeu-DAla-DLys-NH2 (trifluoroacetate salt)
(Disulfide Bridge Cys1-Cys4 and Cys2-Cys3)

ONE-LETTER SEQUENCE: ACDCRGDCFC-GG-klaklakklaklak-NH2 (S-S bonded C1-C4 & C2-C3)

MOLECULAR FORMULA:

MOLECULAR WEIGHT: 2707.4

STORAGE CONDITIONS: -20 ± 5 °C

CAS REGISTRY NUMBER:

SYNONYMS:

RESEARCH AREA: Cancer

CATEGORY: RGD Peptides »

REFERENCES:
Lahdenranta, J. et al. FASEB J. 10.1096/fj.07-8273com (2007)
Ellerby, H. et al. Nat. Med. 5, 1032 (1999)
Smolarczyk, R. et al. Acta Biochim. Pol. 53, 801 (2006)
Curnis, F. et al. Cancer Res. 64, 565 (2004)
Su, Z. et al. Bioconjug. Chem. 13, 561 (2002).

H-Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-Gly-DLys-DLeu-DAla-DLys-DLeu-DAla-DLys-DLys-DLeu-DAla-DLys-DLeu-DAla-DLys-NH2 (trifluoroacetate salt)
(Disulfide Bridge Cys1-Cys4 and Cys2-Cys3)

H-Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-Gly-DLys-DLeu-DAla-DLys-DLeu-DAla-DLys-DLys-DLeu-DAla-DLys-DLeu-DAla-DLys-NH2 (trifluoroacetate salt)
(Disulfide Bridge Cys1-Cys4 and Cys2-Cys3)

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