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Leuprolide Acetate

Leuprolide Acetate

leuprolide-498-204.pngLeuprolide is a nonapeptide GnRH (LHRH) analog (pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt) that stops the pituitary gland from producing luteinizing hormone. This action leads to a reduction in testosterone levels, which may help to shrink the tumor or slow its growth.

Leuprolide may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), to treat precocious puberty, and to control ovarian stimulation in In Vitro Fertilization (IVF). It is considered a possible treatment for paraphilias. Leuprolide also has been tested as a treatment for reducing sexual urges in pedophiles and other cases of paraphilia.

PRODUCT NAME:   Leuprolide Acetate
SEQUENCE:   pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
MOLECULAR FORMULA:   C59H84N16O12
MOLECULAR WEIGHT:   1209.4
CAS REGISTRY NUMBER:   [53714-56-0]
SYNONYMS:   Leuprorelin, Lupron
CLINICAL AREA:   Hormone-Responsive Cancers
DMF SCHEDULE:   US FDA 5/2015; CFDA: Approved 2009
MANUFACTURER:   CPC Scientific Inc.
FDA REGISTRATION #:   29355
TYPE:   Ⅱ (Drug Substance, Drug Substance Intermediate, and Material Used in Their Preparation, or Drug Product)