To better serve our customers, CPC Scientific now offers a variety of peptide databases to help facilitate their research and clinical development.
Therapeutic Peptide Database
This therapeutic peptide database has been adapted from previously published database, THPdb.1 The database is a comprehensive source of FDA-approved and approved/investigational therapeutic peptides (synthetic and recombinant), including peptide API's with different formulations and brand names. Searchable fields include:
Tumor Cell Targetng Peptide Database
This tumor targeting/homing databases was adapted from published database, TumorHoPe2 and contains experimentally referenced tumor targeting peptides that specifically recognize tumor cells and associated microenvironments. Searchable fields include:
Cell-Penetrating Peptide Database
The Cell-Penetrating Peptide (CPP) Database was adapted from the published work of Usmani and associated curated database, CPPsite3. This database is particularly helpful for the design of custom peptide and peptide therapeutic development. It is often advantageous for peptide therapeutics to passively permeabilize cellular membranes because drugs delivered systemically need to exit the blood steam through the membranes of endothelial cells. Passive membrane permeability is also required for drugs to clear (i.e., clearance rates) body through the cell membranes in the kidney. CPPs share many common features that include, (1) short length (10-30 AA), (2) cationic or amphipathic (containing Arg and Lys residues), and (3) water solubility. These peptides can be categorized into synthetic, protein-derived, or chimeric types and distinguished by their chirality (e.g., L-form, D-form, or Mixed), cyclic vs. linear, and by the type of cargo (e.g., fluorophores, nucleic acid, proteins, peptides, nanoparticles, and small molecule drugs) they deliver.Searchable fields include:
- Usmani, S.S., Bedi, G., Samuel, J.S., Singh, S., Kalra, S., Kumar, P., Ahuja, A.A., Sharma, M., Gautam, A. and Raghava, G.P., 2017. THPdb: Database of FDA-approved peptide and protein therapeutics. PloS One, 12(7), p.e0181748.
- Kapoor, P., Singh, H., Gautam, A., Chaudhary, K., Kumar, R. and Raghava, G.P., 2012. TumorHoPe: a database of tumor homing peptides. PLoS One, 7(4), p.e35187.
- Gautam, A., Singh, H., Tyagi, A., Chaudhary, K., Kumar, R., Kapoor, P. and Raghava, G.P.S., 2012. CPPsite: a curated database of cell penetrating peptides. Database, 2012.